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Researchers have established that if the antithyroid drugs carbimazole (or methimazole) are stopped 3-5 days before RAI, they do not influence the effectiveness of RAI. Propylthiouracil (PTU), however, appears to take longer to clear out of the system, and makes a patient more resistant to RAI therapy, and should, therefore, be stopped at least two weeks prior to RAI. If the PTU cannot be stopped, a higher dose of RAI's photo.